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6028 S. Fort Apache Road, Suite 101,  Las Vegas

Complex Strabismus and Syndromes

Some patients exhibit complex combinations of vertical, horizontal, and torsional strabismus.

Dr. Shin treats patients with complex strabismus arising from, but not limited to, thyroid-related eye disease, stroke, or brain tumors as well as strabismic disorders following severe orbital and head trauma.

The following paragraphs describe specific ocular conditions marked by complex strabismus.

Duane Syndrome

Duane syndrome represents a constellation of eye findings present at birth that results from an absent 6th cranial nerve nucleus and an aberrant branch of the 3rd cranial nerve that innervates the lateral rectus muscle.

Duane syndrome most commonly affects the left eye of otherwise healthy females. Duane syndrome includes several variants of eye movement abnormalities.

In the most common variant, Type I, the eye is unable to turn outward to varying degrees from the normal straight-ahead position.

In addition, when the patient tries to look straight ahead, the eyes may cross. This may lead a person with Duane syndrome to turn his/her head toward one side while viewing objects in front of him/her in order to better align the eyes.

When the involved eye moves toward the nose, the eye retracts slightly back into the eye socket causing a narrowing of the opening between the eyelids. In Type II, the affected eye possesses limited ability to turn inward and is generally outwardly turning.

In Type III, the eye has limited inward and outward movement. All three types are characterized by anomalous co-contraction of the medial and lateral rectus muscles, so when the involved eye moves towards the nose, the globe pulls back into the orbit, and the vertical space between the eyelids narrows.

The eye may also drift up (upshoot) or down (down shoot) as it moves toward the nose.

Although restoration of full eye movements in patients with Duane syndrome may not be possible, eye muscle surgery can effectively correct eye misalignment in primary (straight ahead) gaze, eliminate an abnormal head position, and expand one’s field of single-binocular vision, especially if performed early in the patient’s life.

If the abnormal up and down movements of the eye or the narrowness of the eyelid opening significantly affects eye appearance, surgery may also be of benefit.

Brown Syndrome

Brown syndrome is a condition typically present at birth but sometimes acquired later in life in which the affected eye is unable to move upward, especially when it is turned in toward the nose.

This is caused by the inability of the superior oblique muscle, one of the muscles on the top of the eye, to slide through its natural pulley along the nasal bony wall of the eye socket.

This condition is often first noted when upward floating of the uninvolved eye is seen as the affected person looks to the side opposite the affected eye. Alternately, patients may exhibit a Y pattern eye misalignment, i.e. exotropia or outward turning of the eyes in upgaze.

Brown syndrome is sometimes an incidental finding on an eye examination and does not necessitate treatment. However, if the involved eye is lower than the other eye when the individual is looking straight ahead or a chin-up position is needed to keep the eyes aligned, eye muscle surgery should be considered.

Third Nerve Palsy

Third nerve palsy refers to a weakness of the nerve that supplies impulses to four of the six extraocular muscles, to a muscle that elevates the eyelids, and to the pupil. This may be congenital or acquired following head trauma, brain tumor, stroke, or cerebral aneurysm.

The affected eye is generally turned outward (exotropia) and downward (hypotropia). At times, there is an associated droopy eyelid (ptosis) or enlarged pupil.

Occasionally a congenital or acquired third nerve palsy can “regenerate” spontaneously over the course of six months. While we wait to see if the third nerve palsy resolves without intervention, the patient may occlude one lens in glasses or cover one eye to help alleviate diplopia.

If the strabismus arising from a third nerve palsy remains stable but significant, eye muscle surgery can be performed to eliminate ocular misalignment and restore single vision, at least in primary gaze.

A droopy upper lid can confound the patient’s ability to use the realigned eye. In that case, ptosis repair following strabismus surgery is then warranted.

Fourth Nerve Palsy (a.k.a. Superior Oblique Palsy)

Beginning in the brainstem and traveling to different areas of the head and neck are 12 cranial nerves, each of which has a specific function.

A fourth nerve palsy refers to a weakness of the nerve that supplies impulses to the superior oblique muscle, a muscle on the top of the eye whose main function is to move the eye downward and whose secondary function is to rotate the eye inward.

If this muscle is weak, the eye tends to drift upward (hypertropia) and sometimes rotate outward (a type of cyclotropia).

A fourth nerve palsy is often congenital and diagnosed in infancy. On the other hand, signs and symptoms of a congenital fourth nerve palsy may not appear until later in childhood or in adulthood.

In addition, older children and adults can acquire this form of vertical strabismus, for example, with trauma. In acute cases, it may take four to six months to improve or resolve, if at all. Most patients with an isolated fourth nerve palsy have no known underlying cause.

Signs of a Fourth Nerve Palsy

Adults with a fourth nerve palsy are frequently bothered by double vision. In acquired cases, patients may complain of apparent tilting of objects. In children and adults, a noticeable vertical deviation of the eyes is not always the initial sign.

Rather, an individual with a fourth nerve palsy often manifests a head tilt (torticollis) to the side opposite the palsied eye to compensate for the strabismus and to minimize the vertical misalignment. The head tilt permits the affected child or adult to experience binocular vision and depth perception.


Prisms in the form of a plastic film that adheres to glasses or correction that is ground into glasses may alleviate symptoms of diplopia or tired eyes (asthenopia) in adult patients with a small eye deviation. Eyeglass prisms bend light and shift the image up, down, left, or right depending on how it is positioned in or on the glasses.

They allow the patient’s misaligned eyes to work together. They are usually prescribed for small degrees of ocular misalignment since the stronger they are, the more they degrade images, and the thicker and heavier they make glasses if ground in.

Some patients are intolerant of prisms, even if they are of small power. Moreover, prisms do not help align images when they are rotated.

Because of the magnitude of eye misalignment and a rotational component of fourth nerve palsies, prisms are usually not appropriate. Therefore, eye muscle surgery is generally recommended as the treatment for fourth nerve palsy in adults and children.

Following a corrective eye muscle procedure, the associated abnormal head tilt usually decreases or disappears. Patients may require more than one strabismus operation to eliminate the eye misalignment, especially if a fourth nerve palsy of one eye becomes unmasked after the treatment of a fourth nerve palsy of the other eye.

Sixth Nerve Palsy

Sixth nerve palsy refers to a weakness of the nerve that supplies impulses to the lateral rectus muscle, the eye muscle that mainly moves the eye outward. This is usually an acquired condition that presents with gradual or sudden onset of eye-crossing, double vision, and the inability of the eye to move outward.

An abnormal face turns to the side of the paretic sixth nerve that may occur in order to relieve double vision. Causes of sixth nerve palsies include viral illnesses, head trauma, and brain tumors. Small blood vessel disease associated with diabetes or high blood pressure is a common cause of sixth nerve palsies in adults.

Sixth nerve palsies generally improve over the course of several (sometimes up to six months). After a period of observation, if recovery is incomplete and residual eye-crossing remains, eye muscle surgery can eliminate the eye-crossing in straight-ahead gaze and relieve symptoms of double vision.

Restoring single vision in right and left gaze in addition to primary gaze depends on the severity of the sixth nerve palsy and the surgical procedure performed.

Thyroid-Related Eye Disease

Thyroid-related eye disease represents the most common cause of vertical eye deviation in adults. Extraocular muscles enlarge with fluid and lymphocytic infiltration, become inflamed, and then fibrotic.

The extraocular muscles are affected in the following order: Inferior, medial, superior, and lastly, the lateral rectus muscles. These changes cause the affected muscles to become asymmetrically or unequally tight, which leads to restricted eye movements, lid retraction, and prominent-appearing eyes.

Sometimes patients benefit from orbital, eye muscle, and lid surgery, in that order. These changes can occur even with normal thyroid bloodwork.

Our Location

6028 S. Fort Apache Road, Suite 101
Las Vegas, Nevada 89148

Phone: phone 702.896.2020
Fax: 702.896.2025

Conveniently located on South Fort Apache Rd between West Russell Rd and West Sunset Rd (near Patrick Rd)

Open Mon to Thurs from 8am - 5pm, and Friday from 8am - 4:30pm.